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It can be related to poor coordination, muscle weakness, or neurological issues

Traumatic longitudinal melanonychia: The two common types of traumatic longitudinal melanonychia are nail pigmentation associated with onychotillomania (nail biting) and frictional melanonychia, which typically involves the fourth and/or fifth toenails due to friction with shoes[109]

These outcomes were assessed as the changes in 1st- and 2nd-year follow-up from baseline

Cost is usually the next worry, and it is a fair one

277 The evolution of lncRNA-specific and synaptic function-enriched gene expression in primates suggests that this category of RNAs may have a broad range of roles in the brain and may help to elucidate the aetiology of ASD