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Proc Natl Acad Sci 103(12):43864391 Xin W, Feng S, Freisheim JH, Gentry LE, Ratnam M (1992) Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates

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preparing racemic 4-chloro- 3 -hydroxy butyric acid alkyl ester of Formula 3 from the racemic 4-chloro-3-hydroxybutyronitrile of Formula 2 in the presence of an alcohol and a sulfuric acid catalyst