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Am J Physiol Endocrinol Metab 299(4):E624E632 Gutzwiller JP, Drewe J, Gke B, Schmidt H, Rohrer B, Lareida J et al (1999) Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2
It amplifies perimenopausal symptoms
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Notably, Through a feedback mechanism, mTORC1 inhibition may momentarily increase mTORC2 signaling, causing temporary metabolic disruptions during the first phase of treatment (224), which can transiently disrupt metabolism and frequently leads to hyperlipidemia, necessitating concomitant lipid-lowering therapy (237239)
In other cases, a clinicians involvement seemed to be overstated
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