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Butler, P

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Conducted across 170 Veterans Affairs hospitals, the study showed a 13% reduction in major AF-related events, including hospitalizations and ablation procedures, with the greatest benefits seen in patients with severe obesity

It is also endogenous, meaning it is always in our bodies, and is naturally found in most cells

Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration