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Leucine-, arginine-, and methionine-derived SAM can bind their sensors during high intracellular concentrations, thereby disrupting the interaction of the sensors with GATOR1/2, relieving the inhibition of GATOR complex, and activating mTORC1

This is achieved by integrating the PD-1/PD-L1 complex small molecule inhibitor BMS-202 with a cell membrane-anchoring peptide RKC and a near-infrared-activated semiconductor polymer photosensitizer YBS (Wang et al., 2023)

Tenemos delivery

Because these medications operate through separate biological systems, direct pharmacological interactions are rare

Thankfully, the gastrointestinal complications listed above are rare