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Cerebral folate deficiency and CNS inflammatory markers in Alpers disease

Although some studies have shown no efficacy of histone deacetylase inhibitors on mortality in pig models of HS [117, 118], a meta-analysis including 101 studies exploring the effect of histone deacetylase inhibitors (specific and nonspecific) on both rodents and pigs in the context of ischemiareperfusion, sepsis, and severe trauma clearly demonstrated an effect of histone deacetylase inhibitors on the mortality of treated animals [119]

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INOSITOL: Plays an important role in the health of brain cell membranes and neurotransmitter signaling

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