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By screening in four different media conditions, we uncovered their metabolic regulation, including the fitness defects in the mitochondrial folate transporter SLC25A32 KO cells that can be buffered in galactose condition due to substrate limitation in de novo purine biosynthesis
As far as MCFG resistance is concerned, from our data a role of glutathione metabolism in supporting this condition is not evident
doi: 10.3389/fimmu.2020.607891 170 SeifertOBaerwaldC
H 2 O 2 also generated through oxidative processes of MAO and XO that are present in the outer mitochondrial membrane and cytosol respectively
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