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Karmarkar and Tischkau, 2013)

Further consistent with this mechanism, Gem pretreatment did not suppress ferroptosis induced by the direct GPX4 inhibitor ML162, whose ability to induce ferroptosis is independent of intracellular GSH pools (Yang et al, 2014) (Fig 4F)

For the same reason above, it is possible that dehydro-alanine (acrylate) glutathione can inactivate the binding capacity of GCLC to form the holo-enzyme

Little information is available on stability, but one study found it to be stable in water between pH 4.5-7.4 at 60C for at least two weeks, suggesting both aqueous and some thermal stability

10.1136/bmj.322.7297.1271