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The FDA-approved criteria require a BMI of 30 or greater (obesity), or a BMI of 27 or greater with at least one weight-related comorbidity such as type 2 diabetes, high blood pressure, high cholesterol, obstructive sleep apnea, or cardiovascular disease

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Other anamolies of the PDC include autoantibodies leading to paediatric biliary cirrhosis [47].Additionally, the aberrant down-regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation has been shown to be contributory to hyperglycemic states observed in type-2 diabetes [25], increasing the chances of pyruvate dehydrogenase complex as a therapeutic target for a 150 million people affliction i.e

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doi: 10.3390/MEDICINA58020224 72 ChaiSLiuFYangZYuSLiuZYangQet al