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Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types

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This has even been achieved in lower eukaryotes such as Saccharomyces cerevisiae , where a significant resistance to chlorambucil and doxorubicin (eight- and 16-fold, respectively) was reported in cells transfected with mammalian GST isozymes (Black et al ., 1990)

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Men should contact their GP or trial clinician promptly if they experience severe abdominal pain, persistent vomiting, signs of dehydration, or any unexpected symptoms