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The Role of NRF2 in Mitigating Oxidative-Stress-Induced HSC Activation NRF2 activation plays a crucial role in ameliorating liver fibrosis by interfering with the activation of HSCs, which are the key drivers of excessive ECM production

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Consistently, GSH depletion or silencing of Fe-S cluster-associated GLRXs disrupts mitochondrial redox balance, promotes iron overload, and sensitizes cancer cells to ferroptosis 133,134