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Interestingly, ACE2 may not be involved in all processes induced by the spike protein

Martel C, Huynhle H, Garnier A, Ventura-Clapier R, Brenner C (2012) Inhibition of the mitochondrial permeability transition for cytoprotection: direct versus indirect mechanisms

Moreover, HGF is able to directly target activated eosinophils through the downregulation of inflammatory mediators during allergic response (Ito et al., 2005)

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Improvement in cognitive function may be attributed to upregulation of brain-derived neurotrophic factor (BDNF) and neurotrophic factor-3 (NT-3) levels by cAMP response element binding protein (CREB) activation in the brain