Data availability The snRNA-seq data are available in the GEO under SuperSeries accession number GSE288514
Goal: Maintain testicular volume and function during TRT Approach: HCG 500 IU subcutaneously every other day (3x weekly) Begin same time as testosterone therapy Continue for duration of TRT Monitoring: Baseline testosterone, estradiol, LH, FSH Recheck at 6 weeks, then quarterly Adjust based on estrogen response Expected results: Maintained testicular size Preserved fertility potential Possible slight testosterone boost above TRT alone Protocol for fertility restoration on TRT Men on TRT who want to conceive face a decision
However, clinical trial results are not the only factor that matters in real-world decision-making
Semaglutide may cause weight loss including the loss of facial fat, which could lead to a more noticeable facial structure and contours
Because semaglutide enhances insulin secretion and slows carbohydrate absorption, patients continuing their original insulin regimen may experience dangerously low blood glucose events, especially at night or between meals
