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68,69 Adverse effects of GLP-1RA include gastrointestinal side effects (nausea, vomiting, diarrhea), increased heart rate, and injection site reactions
Research from the STEP trials (semaglutide) and SURMOUNT-4 (tirzepatide) shows that without ongoing pharmacotherapy or substantial behavioral interventions, significant weight regain occurs within the first year after stopping treatment
Their work extends beyond traditional rehabilitation models, focusing on helping people understand their bodies, manage symptoms safely, and build sustainable ways of living with chronic illness
Market evolution has consistently favored clinical superiority over theoretical convenience, with Lillys displacement of Novo Nordisk exemplifying how efficacy advantages translate to market leadership
