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Murrough et al., 2010
TLDR: GLP-1, GLP-2, and peptide-related therapies may require small-volume syringes with clear markings, commonly known as U-100 insulin syringes or compatible Luer lock syringes when medication requires a detachable needle
doi: 10.1093/cvr/26.10.956
The molecule was too unwieldy to be a pill At a molecular weight of 1,815 daltons, AOD9604 is a large drug, around five or six times the size of a typical small molecule
The mechanism VEGF-A upregulation (ELISA, RT-qPCR), VEGFR2 phosphorylation (pY1175 western blot), and eNOS Akt-Ser1177 phosphorylation (NO bioavailability for vasodilation and tube formation) is well-characterised
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