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2022 R&D Spend: In 2022, Amgen spent $4.43 billion on R&D, a 7.99 percent decrease from the $4.82 billion the company spent on R&D in 2021

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In pasireotide, cyclization between the N- and C-termini extends its half-life to 12 h, making it particularly effective for treating Cushings disease compared to other somatostatin analogues (Figure , Table )

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